HELIXIA-COLL™ engineers compact, bioactive proteins inspired by human collagen, bringing the precision of biotechnology to the next generation of cosmetics.
Collagen-inspired, enhanced performance, and free from animals.
HELIXIA-Coll™ · Regenerative skin longevity
Repair. Restore. Reactivate.
A new generation of animal-free recombinant collagen peptides for advanced skincare. HELIXIA-Coll™ brings together human-inspired protein design, precision fermentation and biological evaluation to support premium cosmetic development.
01
Oxidative stress protection
HELIXIA-Coll™-17 helps maintain low intracellular ROS levels in human dermal fibroblasts and delivers enhanced protection under oxidative stress.
02
Supports skin renewal
Supports epidermal cell migration in vitro, a cellular response associated with skin renewal and barrier-care positioning.
03
Matrix-renewal signaling
Shows a collagen-associated matrix response in fibroblasts, supporting skin-renewal, barrier-care and age-care cosmetic applications.
04
Exceptional stability
Stable and soluble from pH 2.0 to 8.5 at concentrations up to 10 g/L. Intrinsic stability supports formulation development.
Ingredient-level research includes physicochemical characterization and in vitro studies. Performance and claims should be validated in the final formulation.
Engineered recombinant human collagen XVII. Designed through synthetic biology to enhance skin penetration and biological performance. Reduces oxidative stress and promotes skin cell migration, supporting healthy skin aging.
Human-inspired. Rationally designed.Selected collagen XVII-derived sequences in a compact recombinant molecular format.
Animal-free production.Produced through precision fermentation with a defined protein design.
Intrinsic integrity. Exceptional stability.Designed to retain collagen structure across physicochemical conditions, without additional excipients for intrinsic stability.
Rationally designed recombinant collagen peptides engineered to preserve key endogenous biological functions in a compact molecular format designed for skin delivery. A platform of animal-free biomolecules for premium cosmetics and future biomedical applications.
17Flagship
HELIXIA-Coll™-17
Skin renewal
Inspired by collagen XVII. Engineered to support epidermal resilience and renewal-associated signaling, helping maintain skin integrity and a healthier dermal–epidermal interface.
Commercial status
Lead commercial candidate · CDMO-ready
3Platform
HELIXIA-Coll™-3
Skin elasticity
Inspired by collagen III. Engineered to support extracellular matrix remodeling, with a focus on matrix organization, skin elasticity and tissue quality.
Commercial status
CDMO-ready
1In development
HELIXIA-Coll™-1
Skin firmness
Inspired by collagen I. Designed to support cell–matrix interactions and extracellular matrix organization, with a focus on structural tissue support and skin firmness.
Human collagen XVII connects basal epithelial cells to the basement membrane. This biology provides the starting point for the design of HELIXIA-Coll™-17.
Figure 1. Structure, interactions and signaling of native human collagen XVII. Original figure from the HELIXIA-17 technical datasheet.
A connection at the foundation of skin.
Collagen XVII is a transmembrane component of hemidesmosomes, contributing to epidermal adhesion and the organization of the dermal–epidermal interface.
ArchitectureIntracellular, transmembrane and extracellular domains connect the cell interior with its surrounding matrix.
InteractionsLaminin-332, integrins, BP230 and plectin form part of this interconnected adhesion system.
SignalingThe diagram maps associated PI3K–Akt signaling and its relationship to cell survival, growth and proliferation.
This figure describes native collagen XVII biology. It provides design context for HELIXIA-Coll™-17; it does not establish an experimentally demonstrated mechanism for the engineered ingredient.
From design to validation
A defined molecule.
A connected development pathway.
Sequence selection, protein engineering, precision fermentation and cell-based evaluation connect the biological inspiration to an ingredient development program.
01
Select
Identify collagen XVII-inspired sequences for solubility and receptor-binding design.
02
Engineer
Combine selected sequences into a compact recombinant construction.
03
Produce
Use recombinant expression in yeast and precision fermentation.
04
Evaluate
Characterize physicochemical properties and biological activity in cell-based assays.
Figure 2. HELIXIA™-17 construction pipeline. Original technical figure showing sequence selection, molecular modeling and recombinant protein construction.
Orlando Vargas · Precision fermentation at Luyef Biotechnologies.
Engineered by Luyef · Made through biology
From bioreactor
to your formulation.
We bring protein design, biomanufacturing and biological evaluation together to develop high-value ingredients for cosmetic innovators.
Synthetic biologyRational design of proteins and peptides around a defined biological purpose.
Precision fermentationAnimal-free production through engineered microorganisms.
Cell-based technologiesIn-house evaluation of biological activity to guide the next development step.
0.01–0.1% w/vSubject to formulation-specific evaluation
Technical support
Samples, CoA, technical data and incorporation guidance
Supporting technical characterization
Physicochemical and exploratory in vitro studies inform ingredient development. Discuss methods, conditions and interpretation with our scientific team.
Thermal stability characterization · Technical datasheet.Exploratory gene-expression analysis · In vitro.Cell viability under basal and oxidative stress conditions · In vitro.
Matrix-renewal signaling includes an exploratory in vitro dataset in NIH 3T3 fibroblasts. Full technical data and development support are available through our scientific team.
From ingredient to brand experience
Your next skincare innovation.
Powered by HELIXIA.
A distinctive animal-free ingredient story, supported by protein engineering, precision fermentation and a scientific development pathway. Connect the ingredient, the formulation and the experience your brand brings to consumers.
FORMULATORS & R&D
Evaluate the ingredient.
Discuss the data, explore a sample and define compatibility, stability and performance testing for your formulation.
Talk to our scientific team ↗Open in Gmail ↗COSMETIC BRANDS
Build a signature product.
Explore HELIXIA for a premium skincare concept, with a clear ingredient identity and a compelling consumer story.
Explore a brand partnership ↗Open in Gmail ↗MANUFACTURING & DISTRIBUTION
Inspired by nature. Driven by science. Engineered by Luyef.
THE SHIFT
Animal collagen hasn't kept up with the industry.
For decades, cosmetic collagen has meant animal-derived material: variable, hard to standardize, and increasingly out of step with what brands and consumers expect. It’s also large, generic, and passive. The market is moving toward ingredients that are consistent, animal-free, and engineered for precise functionality. Traditional collagen wasn’t built for that.
OUR ANSWER
Proteins designed with intent.
Instead of extracting whole collagen, we use biotechnology to produce recombinant proteins designed from the specific functional regions of human collagen. The result is a new class of bioactive, animal-free proteins: smaller and more defined than animal collagen, engineered to perform in cosmetic formulations and supported by laboratory and cell-based research.
BIOTECHNOLOGY DESIGN
Engineered from the functional regions of human collagen using a validated recombinant system.
ANIMAL-FREE BY DESIGN
Produced through biotechnology, with no animal sourcing.
COMPACT AND BIOACTIVE
Sequence selected for transmembrane receptor affinity. Designed to interact with living skin cells, not just sit on the surface.
SCIENTIFICALLY-BACKED FUNCTIONALITY
Demonstrated stimulation of skin-cell proliferation and protection.
FROM BIOLOGY TO PROTEIN
How we design them.
01
Identify
We start from specific functional regions of human collagens.
02
Design & Express
We engineer compact and highly maleable recombinant proteins and produce them through biotechnology.
03
Deliver
We provide bioactive, animal-free proteins ready for cosmetic development.
PRODUCT PORTFOLIO
Our Recombinant Collagens
Helixia™-17
Inspired by human collagen XVII
Helixia™-3
Inspired by human collagen III
More in development
BUILT FOR COSMETICS
Intrinsic integrity, enduring results.
pH 2-9
Stable and soluble across a wide pH range
Up to 10 g/L
High solubility for flexible loading
25 to 99°C
Thermostable
Biocompatible
Compatible with skin tissue
Firmness support
Supports skin’s structural appearance
Matrix support
Supports matrix-related skin appearance
THE DIFFERENCE
What is improved.
ANIMAL COLLAGEN
● Supply tied to animal and marine sourcing
● Large structure
● Variable batch to batch
● Origin increasingly questioned
THE HELIXIA™ APPROACH
● Designed from human collagen biology
● Compact, defined and consistent by design
● Animal-free biotechnology
● Scalable, biotech-based production
Let's build what's next in cosmetics.
Whether you’re formulating a breakthrough product, scouting new ingredients, or exploring what biotechnology can do for your brand, we’d like to hear from you. Tell us what you’re working on, and our team will be in touch.
